CMERI has one office campus and three residential campuses in Durgapur. Office campus spans in an area of 81 acres with more than 16 buildings. The campus is located 7.80 kilometers from Durgapur railway station and 1.6 kilometers from Durgapur City Center. The campus is adjacent to National Institute of Technology, Durgapur and National Power Training Institute, Durgapur. An extension center of CMERI, Durgapur is situated in Ludhiana, an industrial town of Punjab.

Three residential campuses extended over 72 acres of land and has civic amenities like Staff Quarters, Scientist Apartments, Children Park, Health Center, Staff Club, Guest Houses, Executive Hostels, Academic Hall of Residence, Dispensary, Market, Gymkhana and Schools. Kendriya Vidyalaya is situated inside the campus for providing the education from primary to higher secondary students and meant mainly for ward of the employees. A state-funded free primary school named Shishu Bani is also available in the campus to serve the educational need of nearby poor people. The institute also runs a free children computer training center named CSIR Kids' i-zone, which is situated in the colony campus.